Andres Guardado and Hector Moreno are fit to start for Mexico in El Tri's final match before the World Cup.
Diego Reyes' fitness, on the other hand, continues to be of concern with the defender/midfielder not in the squad to face Denmark.
Reyes returned to training along with the team Thursday with Osorio expressing hope the 25-year-old could take part in Saturday's game, but a hamstring injury looks to keep Reyes from playing this match. It likely will keep him out of the World Cup as well with Erick Gutierrez set to take his place in the team.
Osorio elects to start with a group that gives some of his biggest stars a rest, with players like forwards Hirving Lozano and Javier "Chicharito" Hernandez not in the first XI. That allows center forward Oribe Peralta to get his first Mexico start of 2018.
Rafa Marquez and Miguel Layun also begin on the bench. The probable back four to face the Danes is Carlos Salcedo at right back, Hugo Ayala at right center back, Hector Moreno and left center back and Jesus Gallardo at left back.
The midfield contains Guardado, who will play his first minutes since finishing the season with Real Betis and undergoing a procedure on his leg to deal with a nerve issue. He's joined in the midfield by Hector Herrera, who missed a day of training this week to deal with a personal matter. He was photographed with several other players at a party after Mexico's 1-0 win Saturday over Scotland. Jonathan dos Santos rounds out the center three.
His brother, Giovani dos Santos, looks to be starting up top as an inverted winger to Peralta's right while Jesus "Tecatito" Corona rounds out the field players.
Guillermo Ochoa starts in goal.
Mexico XI: Ochoa; Salcedo, Ayala, Moreno, Gallardo; J. dos Santos, Herrera, Guardado; G. dos Santos, Peralta, Corona