Pep Guardiola called up 22 players to play the first leg of the Champions League round of 16 match at Red Bull Arena in Germany, which starts at 20:00 UK time on Wednesday 22nd February.
Kevin De Bruyne and Aymeric Laporte, who started in Saturday's match against Nottingham Forest, did not travel with the team. John Stones, injured since the victory over Arsenal in the FA Cup, also did not travel.
Guardiola revealed that De Bruyne and Laporte are absent due to illness.
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"Kevin and Laporte will not play because they are ill," said the coach in his pre-match press conference. "They are not ready for tomorrow."
"It is what it is. Unfortunately, sometimes that happens during the season."
"De Bruyne didn't feel well right after the match against Nottingham. Yesterday, Ayme wasn't feeling well."
"Other players will play. These situations happen sometimes."
Guardiola expects a difficult match against RB Leipzig, who have only been defeated once in their last 20 matches in all competitions.
They have also won their last four group stage matches in the Champions League and qualified for the round of 16, including a victory over the reigning champion, Real Madrid.
The Manchester City manager emphasized the quality of the opponent:
"Right after the draw, I already knew that Leipzig would be a tough opponent. This club has a lot of culture with young players. They are a very physical team, with many players in midfield. I have great respect for what they have done so far."
"Last year, when they had Jesse Marsch and Christopher Nkunku, we had problems when we played against them. We lost here in Leipzig. We had already qualified, but it was a tough match."
"It will be two very difficult matches. We must play at a good level and control our emotions. We must achieve a good result for the second leg match in Manchester."