The Week 10 college football schedule brings some especially important matchups in the SEC and ACC. The Tennessee Volunteers were unveiled as the No. 1 team in the College Football Playoff Rankings on Tuesday. However, the Volunteers are 8-point underdogs at Georgia according to the latest Week 10 college football odds from Caesars Sportsbook. Elsewhere in the SEC, the sixth-ranked Alabama Crimson Tide are favored by 13.5 points on the road against No. 10 LSU.
Over in the ACC, No. 21 Wake Forest is laying 4.5 points against No. 22 NC State in the latest Week 10 college football spreads. Which college football lines should you be targeting this weekend? Before making any Week 10 college football picks, be sure to see the latest college football predictions from SportsLine's advanced computer model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, it has turned its attention to the latest Week 10 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.
Top college football predictions for Week 10
One of the college picks the model is high on in Week 10: No. 4 Clemson (-3.5) cruises to an easy win at Notre Dame on Saturday night. The Tigers have scored 30 or more points in seven of their eight games this season. Clemson currently features the 19th-ranked scoring offense in the country, averaging 37.1 points per contest.
Clemson's offense has been extremely efficient on 3rd downs in 2022, converting 48.4% of the time. Running back Will Shipley is a major reason for Clemson's success. The sophomore RB has rushed 123 times for 739 yards and 10 touchdowns. He's averaging 6.0 yards per carry and now he'll face a Notre Dame defense that's giving up 129.1 rushing yards per game. SportsLine's model is projecting Shipley will average over 5.0 yards per carry against the Fighting Irish, helping the Tigers cover the spread well over 60% of the time.
Another one of the model's top college football picks: Auburn (+13) stays within the double-digit spread against Mississippi State. The Bulldogs are coming off several shaky performances in a row, including a blowout loss to Alabama their last time out. They also suffered a double-digit loss to Kentucky in mid-October and fell to LSU by 15 points in September. Mississippi State has not had much success in this series historically, losing 14 of the last 20 games.
The Tigers have covered the spread in four of the last six meetings between these teams. They have had some success against unranked conference foes this season, beating Missouri and losing to LSU by four points. Junior running back Tank Bigsby will allow Auburn to control most of the possession on Saturday night, which is one reason why the Tigers are covering the spread almost 70% of the time. See which other teams the model likes here.
How to make college football picks for Week 10
The model has also made the call on who wins and covers in every other FBS matchup in Week 10, and it says several top-25 teams will go down hard. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence? And which top-25 teams go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.
College football odds for Week 10 (via Caesars)
See full Week 10 college football picks, odds, predictions here
Thursday, Nov. 3
UTEP at Rice (-4, 47)
Appalachian State at Coastal Carolina (+3, 64)
Friday, Nov. 4
Duke at Boston College (+10, 47)
UMass at UConn (-15.5, 40)
Oregon State at Washington (-4.5, 54.5)
Saturday, Nov. 5
North Carolina at Virginia (+7, 60.5)
Ohio State at Northwestern (+38, 62.5)
Texas Tech at TCU (-10, 71)
Tennessee at Georgia (-8, 65.5)
Syracuse at Pittsburgh (-3.5, 50.5)
Oklahoma State at Kansas (+3.5, 69)
Liberty at Arkansas (-14, 64.5)