Los Angeles Chargers at Kansas City Chiefs odds, picks and predictions

Analyzing Thursday's Los Angeles Chargers at Kansas City Chiefs odds and lines, with expert NFL picks, predictions and best bets.

The Kansas City Chiefs (1-0) kick off their 2022 homestand against the Los Angeles Chargers (1-0) Thursday at GEHA Field at Arrowhead Stadium. Kickoff time in Kansas City, Mo., is set for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook‘s lines around the Chargers vs. Chiefs odds, and make our expert NFL picks and predictions.

The Chiefs got off to a hot start in Week 1 by defeating the Arizona Cardinals 44-21. QB Patrick Mahomes won AFC Offensive Player of the Week after throwing for 360 yards and 5 TDs.

The Chargers already have a win over an AFC West rival under their belt, beating the Las Vegas Raiders 24-19 in Week 1. Chargers QB Justin Herbert threw for 279 yards and 3 TDs.

Since 1960, the Chiefs lead the all-time series over the Chargers 65-58-1. L.A. is 3-1 ATS in its last 4 games against the Chiefs. The two squads split their series straight up and against the spread 1-1 in 2021. The Chargers won 30-24 as underdogs in their 1st matchup while the Chiefs won 34-28 and covered the spread in the 2nd matchup on a Thursday night.

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Chargers at Chiefs odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:30 p.m. ET.

Money line (ML): Chargers +170 (bet $100 to win $170) | Chiefs -205 (bet $205 to win $100) Against the spread (ATS): Chargers +4.5 (-112) | Chiefs -4.5 (-108) Over/Under (O/U): 54.5 (O: -108 | U: -112)

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Chargers at Chiefs key injuries

Chargers

WR Keenan Allen (hamstring) out TE Donald Parham (hamstring) out CB J.C. Jackson (ankle) questionable

Chiefs

K Harrison Butker (ankle) out RG Trey Smith (ankle) questionable

Chargers at Chiefs picks and predictions

Prediction

Chiefs 38, Chargers 31

Money line

The Chiefs offense appears to be just fine without WR Tyreek Hill, who went to the Miami Dolphins during the offseason. The Bolts will be missing a key cog with WR Keenan Allen (hamstring) out. With that in mind, it’s tough to consider the Chargers with the money line here, and the Chiefs’ money line doesn’t provide a good enough payout to make it worth consideration. Go ahead and PASS on the money line unless you’re including it in a parlay.

Against the spread

I would lightly play CHIEFS -4.5 (-108) based on their Week 1 domination over the Arizona Cardinals. The Chiefs and Chargers usually play each other close, but keep in mind both of their matchups in 2021 were decided by 6 points.

Over/Under

The OVER 54.5 (-108) seems like the safest bet. These teams scored 54 and 62 total points in their 2 matchups last season and put up a combined 68 points last week. This game is poised to be another thriller like last season’s Thursday night matchup.

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