Melgar could join the last two national clubs that achieved the feat.
The recent rout of Independiente del Valle against Melgar in the 2022 Copa Sudamericana leaves open the possibility of a historic comeback, as has happened in previous years.
It happened in the 1993 Copa Libertadores. Sporting Cristal had lost 3-0 to El Nacional from Ecuador in the Round of 16.
However, in Lima, the team led by José Carlos Amaral achieved a historic 4-0 victory with goals from Pablo Zegarra, Percy Olivares, Flavio Maestri, and Marquinho.
Meanwhile, Universidad César Vallejo in 2014 managed to overturn a negative scoreline in the Round of 16 of the Copa Sudamericana after losing 2-0 to Bahía from Brazil in the first leg.
In the return match, at Estadio Mansiche in Trujillo, the team led by Franco Navarro equalized the result with goals from Ronald Quinteros and William Chiroque, forcing the game to be decided by penalties, where the "poeta" team won 7-6 and secured their place in the quarterfinals.