Here are the appointed referees:
Friday 17/01:
Guaraní vs. San Lorenzo, at the Rogelio Livieres, at 18.00. Referee: Juan López. VAR: Mario Díaz de Vivar.
River Plate vs. Sol de América, at the Jardines del Kelito, at 20.15. Referee: David Ojeda. VAR: Ulises Mereles.
Saturday 18/01:
Nacional vs. Guaireña, at the Arsenio Erico, at 18.00. Referee: Carlos Benítez. VAR: Fernando López.
Cerro Porteño vs. Luqueño, at La Nueva Olla, at 20.15. Referee: Derlis López. VAR: Ulises Mereles.
Sunday 19/01:
12 de Octubre vs. Libertad, at the Luis Salinas, at 18.00. Referee: Arnaldo Samaniego. VAR: Mario Díaz de Vivar.
Olimpia vs. General Díaz, at the Manuel Ferreira, at 20.15. Referee: José Méndez. VAR: Juan Gabriel Benítez.